Patent Number: 6,762,322

Title: Preparation of nitrone derivatives

Abstract: Nitrone derivatives are efficiently prepared by increasing reagent concentrations in reaction solutions. Aldehydes and amines may be condensed to prepare an imine intermediate. Elimination of the solution media generally renders the imine formation more efficient. The imine is then reacted with a peroxysulfacte oxidizing agent in a solution having at least about 0.1M concentration of the imine. The oxaziridine is rearranged to produce the nitrone derivative in high yield and good purity.

Inventors: Parker; Dane Kenton (Massillon, OH)

Assignee: Goodyear Tire & Rubber Company

International Classification: C07C 291/00 (20060101); C07C 291/02 (20060101); C07D 273/00 (20060101); C07C 249/00 (); C07C 249/02 (); C07C 249/04 (); C07C 249/12 ()

Expiration Date: 07/12012