Patent Number: 6,794,649

Title: Spectrophotometric determination of gas phase compositions

Abstract: Methods are disclosed for determining the monotonic functional relationship between (A) the integrated absorbance of spectral energy within a spectral region of interest of an analyte (i) that decomposes during the time experimental spectral data for determining the relationship are being obtained, or (ii) whose spectral data are pressure sensitive at pressures below a given pressure, or (iii) that decomposes during the time the spectral data are being obtained and whose spectral data are pressure sensitive and (B) the concentration of the analyte before decomposition commences. Methods are also disclosed for using the monotonic functional relationship to determine the concentration of the analyte in an unknown from the integrated absorbance of spectral energy within the spectral region of interest for the unknown. The methods are useful for determining the concentration of gaseous analytes, such as hydrogen peroxide, whose concentrations must be accurately and rapidly determined in processes such as sterilization processes at the time the processes are being conducted.

Inventors: Thrash; Robert J. (St. Charles, IL), Cullen; Thomas F. (Des Plaines, IL), Khorzad; Davoud (Lake Forest, IL), Fisher; Jimmy (Hawthorn Woods, IL)

Assignee: Pharmaceutical Systems, Inc.

International Classification: G01N 21/31 (20060101); G01N 21/35 (20060101); A61L 002/08 (); G01N 021/00 ()

Expiration Date: 09/21/2021