Patent Number: 6,941,229

Title: Method of designing agonists and antagonists to EGF receptor family

Abstract: The present invention relates to a method of designing compounds able to bind to a molecule of the EGF receptor family and to modulate the activity mediated by the receptor molecule based on the 3-D structure coordinates of the EGF receptor crystal of FIG. 6.

Inventors: Elleman; Thomas Charles (Westmeadows, AU), Epa; Vidanagamage Chandana (Parkville, AU), Garrett; Thomas Peter John (Brunswick, AU), Jorissen; Robert Nicholas (Keysborough, AU), Lou; Meizhen (Scoresby, AU), Burgess; Antony Wilks (Camberwell, AU), McKern; Neil Moreton (Lilydale, AU), Treutlein; Herbert Rudolf (Moonee Ponds, AU), Ward; Colin Lesley (Carlton, AU)

Assignee: Commonwealth Scientific and Industrial Research Organization

International Classification: C07K 14/435 (20060101); C07K 14/71 (20060101); A61K 38/00 (20060101); G06F 019/00 (); G01N 033/48 (); G01N 033/50 (); G01N 033/53 ()

Expiration Date: 09/06/2022