Patent Number: 6,967,214

Title: Inhibitors of IMPDH enzyme

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

Inventors: Armistead; David M. (Sudbury, MA), Badia; Michael C. (Bedford, MA), Bemis; Guy W. (Arlington, MA), Bethiel; Randy S. (Cambridge, MA), Frank; Catharine A. (Langhorne, PA), Novak; Perry M. (Milford, MA), Ronkin; Steven M. (Watertown, MA), Saunders; Jeffrey O. (Acton, MA)

Assignee: Vertex Pharmaceuticals Incorporated

International Classification: A61K 31/422 (20060101); A61K 31/403 (20060101); A61K 31/404 (20060101); A61K 31/42 (20060101); C07C 275/00 (20060101); C07C 275/42 (20060101); C07D 263/00 (20060101); C07D 413/12 (20060101); C07D 263/32 (20060101); C07D 413/00 (20060101); A61K 031/42 (); A61P 031/22 ()

Expiration Date: 1/22/02018