Patent Number: 6,967,242

Title: Antimicrobial 2-deoxystreptamine compounds

Abstract: The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention comprises at least one aryl, heteroaryl, substituted aryl or substituted heteroaryl group in place of a glycosyl group attached to the 2-deoxystreptamine ring.

Inventors: Swayze; Eric (Carlsbad, CA), Griffey; Richard H. (Vista, CA), Ding; Yili (San Diego, CA), Mohan; Venkatraman (Carlsbad, CA)

Assignee: ISIS Pharmaceuticals, Inc.

International Classification: C07H 15/236 (20060101); C07H 15/00 (20060101); C07H 015/22 (); C07H 017/04 ()

Expiration Date: 1/22/02018