Patent Number: 6,967,244

Title: Neuronal nicotinic acetylcholine receptor compositions

Abstract: The present invention relates to a family of neuronal nicotinic acetylcholine receptors comprised of neuronal agonist and non-agonist binding subunits, and DNA sequences encoding such subunits. These novel neuronal nicotinic acetylcholine receptor subunits include the agonist binding subunits alpha2, alpha3, alpha4, and alpha5, plus non-agonist binding subunits beta2, beta3 and beta4. Representative cDNA clones that contain the DNA sequences of the invention have been deposited with the American Type Culture Collection for patent purposes.

Inventors: Heinemann; Stephen Fox (La Jolla, CA), Patrick; James Warner (Houston, TX), Boulter; James Richard (San Diego, CA), Deneris; Evan Samuel (La Jolla, CA), Wada; Keiji (Rockville, MD), Ballivet; Marc Charles (Geneva, CH), Goldman; Daniel Jay (Ann Arbor, MI), Connolly; John Gerard (Del Mar, CA), Duvoisin; Robert Michael (Del Mar, CA), Heinemann; Eden Deer (San Luis Obispo, CA)

Assignee: The Salk Institute for Biological Studies

International Classification: C07K 14/435 (20060101); C07K 14/705 (20060101); C12N 015/12 ()

Expiration Date: 1/22/02018