Patent Number: 7,029,861

Title: LPS-response gene compositions and methods

Abstract: The present invention describes a mutant TLR-4 in mice that does not recognize endotoxin and therefore does not stimulate the secretion of TNF from macrophages. Methods of detecting the mutation are provided; as are methods screening for drugs that may stimulate TNF production. Finally methods of incorporating and expressing the mutant TLR-4 genes into a host cell are contemplated.

Inventors: Beutler; Bruce A. (Dallas, TX), Poltorak; Alexander (Dallas, TX)

Assignee: Board of Regents, The University of Texas System

International Classification: G01N 33/50 (20060101); C07H 21/04 (20060101); C07K 14/00 (20060101); C12N 5/00 (20060101); C12Q 1/68 (20060101)

Expiration Date: 4/18/02018