Patent Number: 7,045,152

Title: Treating pulmonary disorders with gaseous agent causing repletion of GSNO

Abstract: Pulmonary disorders in which the GSNO pool or glutathione pool in the lung is depleted and where reactive oxygen species in lung are increased, are treated by delivering into the lung as a gas, agent causing repletion or increase of the GSNO pool or protection against toxicity and does so independently of reaction with oxygen. Agents include ethyl nitrite, NOCl, NOBr, NOF, NOCN, N.sub.2O.sub.3, HNO, and H.sub.2S. Optionally, N-acetylcysteine, ascorbate, H.sub.2S or HNO is administered in addition to other GSNO repleting agent to potentiate the effect of said agent.

Inventors: Stamler; Jonathan S. (Chapel Hill, NC)

Assignee: Duke University

International Classification: A61K 9/72 (20060101); A61K 31/198 (20060101); A61K 31/375 (20060101); A61K 33/00 (20060101); A61K 45/00 (20060101); A61P 11/00 (20060101); A61P 11/06 (20060101); A61P 9/00 (20060101)

Expiration Date: 5/16/02018