Patent Number: 7,045,326

Title: Mono- and diacylglycerol acyltransferases and methods of use thereof

Abstract: Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase and/or monoacylglycerol acyltransferase activity, as well as the polypeptide products encoded thereby, i.e., mammalian DGAT2.alpha. and MGAT1 polypeptide products, and methods for producing the same, are provided. Also provided are: methods and compositions for modulating DGAT2.alpha. and MGAT1 activity; DGAT2.alpha. and MGAT1 transgenic cells, animals and plants, as well as methods for their preparation; and methods for making diglyceride, diglyceride compositions, triglycerides and triglyceride compositions, as well as the compositions produced by these methods. The subject methods and compositions find use in a variety of different applications, including research, medicine, agriculture and industry applications.

Inventors: Cases; Sylvaine (Belmont, CA), Stone; Scot J. (Fairfield, CA), Zhou; Ping (Walnut Creek, CA), Farese, Jr.; Robert V. (San Francisco, CA), Yen; Chi-Liang Eric (San Francisco, CA)

Assignee: The Regents of the University of California

International Classification: C12N 9/10 (20060101); C07H 21/04 (20060101)

Expiration Date: 5/16/02018