Patent Number: 7,045,329

Title: Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy

Abstract: The enzyme Lp-PLA.sub.2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA.sub.2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.

Inventors: MacPhee; Colin Houston (Letchworth, GB), Tew; David Graham (Groby, GB), Southan; Christopher Donald (London, GB), Hickey; Deirdre Mary Bernadette (Saffron Walden, GB), Gloger; Israel Simon (London, GB), Lawrence; Geoffrey Mark Prouse (Sawbridgeworth, GB), Rice; Simon Quentyn John (Buntingford, GB)

Assignee: SmithKline Beecham plc

International Classification: C12N 9/00 (20060101); C07H 21/04 (20060101); C12N 9/20 (20060101)

Expiration Date: 5/16/02018