Patent Number: 7,045,532

Title: ACE-2 modulating compounds and methods of use thereof

Abstract: ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include compounds of formula (I): Z-.LAMBDA. (I) Wherein Z is a zinc coordinating moiety and .LAMBDA. is an amino-acid mimicking moiety, and pharmaceutically acceptabale salts thereof. Methods of using the inhibitors and pharmaceutical compositions containing the inhibitors to treat a body weight disorder, to decrease appetite, to increase muscle mass, to decrease body fat, to treat diabetes and to treat a state associated with altered lipid metabolism, are also described.

Inventors: Acton; Susan L. (Lexington, MA), Ocain; Timothy D. (Framingham, MA), Gould; Alexandra E. (Cambridge, MA), Dales; Natalie A. (Arlington, MA), Guan; Bing (Brighton, MA), Brown; James A. (Framingham, MA), Patane; Michael (Andover, MA), Kadambi; Vivek J. (Boxboro, MA), Solomon; Michael (Medford, MA), Stricker-Krongrad; Alain (Lexington, MA)

Assignee: Millennium Pharmaceuticals, Inc.

International Classification: A61K 31/194 (20060101); A61K 31/198 (20060101); A61K 31/39 (20060101); A61K 31/415 (20060101); A61K 31/4172 (20060101)

Expiration Date: 5/16/02018