Patent Number: 7,078,418

Title: 1-aziridino-1-hydroxyiminomethyl-derivates, method for the production thereof and medicaments containing said compounds

Abstract: Described are new 1-aziridino-1-hydroxyiminomethyl derivatives with the general formula (I), wherein R is able to is a single bond or a linker moiety capable of covalently bonding two aziridine oxime groups, R.sub.1 and R.sub.2 independently of one another are selected from the group consisting of --H, --CH.sub.3, --C.sub.2H.sub.5, --CN, --COOH, --COOCH.sub.3, --COOC.sub.2H.sub.5, --CONH.sub.2, or --C.sub.6H.sub.5 group, and n is the whole number 2, provided that R.sub.1 and R.sub.2 are not both --H and provided that R.sub.1 is not --H if R.sub.2 is --CH.sub.3 and R.sub.1 is not --CH.sub.3 if R.sub.2 is --H The compounds of general formula (I) show antitumor activity.

Inventors: Kalvins; Ivars (Riga, LV), Adrianov; Viktor (Riga, LV), Shestakova; Irina (Riga, LV), Kanepe; Iveta (Riga, LV), Domracheva; Ilona (Riga, LV)

Assignee: Kalvins; Ivars

International Classification: A61K 31/44 (20060101); A61K 31/33 (20060101); C07D 285/10 (20060101); C07D 401/06 (20060101); C07D 405/06 (20060101)

Expiration Date: 7/18/02018