Patent Number: 7,087,228

Title: Preventing tooth decay and infective endocarditis using natural oligopeptides

Abstract: The present invention provides compositions, medicaments, and methods for the treatment or prophylaxis of conditions associated with the binding of Streptococcus mutans to teeth. Specifically, the present invention provides a method for preventing dental caries and infective endocarditis in a subject by treating the subject's oral cavity with a composition or medicament comprising the competence stimulating peptide (CSP) of the causative bacterium, which inhibits the ability of the said bacteria to attach to the surface of teeth. Novel anti-caries compositions using the CSP are also disclosed.

Inventors: Goodman; Steven D. (Redondo Beach, CA), Kay; Olga (Los Angeles, CA)

Assignee: University of Southern California

International Classification: A61K 39/40 (20060101); C07H 21/04 (20060101); C07K 16/00 (20060101)

Expiration Date: 8/08/02018