Patent Number: 7,087,577

Title: Method of promoting natural bypass

Abstract: An angiogenic factor comprising a mixture of proteins derived from bone. The angiogenic protein mixture is produced by a series of steps that allow the proteins to be kept in solution. The angiogenic mixture of bone proteins is produced by a multi-step process that includes at least one ultrafiltration step, an anion exchange chromatography step, a cation exchange chromatography step and a high performance liquid chromatography (HPLC) purification step.

Inventors: Benedict; James J. (Arvada, CO), Ranieri; John P. (Austin, TX), Whitney; Marsha L. (Austin, TX), Akella; Rama (Austin, TX)

Assignee: Zimmer OrthoBiologies, Inc.

International Classification: A61K 38/18 (20060101)

Expiration Date: 8/08/02018