Patent Number: 7,087,590

Title: 19-norbufalin derivatives, their preparation and pharmaceutical compositions containing them

Abstract: A 19-norbufalin derivative compound of formula (I): ##STR00001## wherein the R groups are as defined by the present specification. The compounds are Na.sup.+K.sup.--ATPase inhibitors and can be used in the treatment of cardiac and/or vascular malfunction, renal malfunction, as digoxin antagonists, for treatment of CNS disorders and for the treatment of malignant and proliferative cell diseases.

Inventors: Lichtstein; David (Jerusalem, IL), Deutsch; Joseph (Jerusalem, IL)

Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem

International Classification: A61K 31/58 (20060101); A61K 31/585 (20060101); C07J 17/00 (20060101)

Expiration Date: 8/08/02018