Patent Number: 7,087,626

Title: Pyrrole derivatives as pharmaceutical agents

Abstract: Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ring and X is C, O or S ##STR00001##

Inventors: Beight; Douglas Wade (Frankfort, IN), DeCollo; Todd Vincent (Noblesville, IN), Godfrey; Alexander Glenn (Greenwood, IN), Goodson, Jr.; Theodore (Indianapolis, IN), Li; Hong-Yu (Zionsville, IN), McMillen; William Thomas (Indianapolis, IN), Miller; Shawn Christopher (Noblesville, IN), Sawyer; Jason Scott (Indianapolis, IN), Smith; Edward C. R. (Fishers, IN), Yingling; Jonathan Michael (Fishers, IN)

Assignee: Eli Lilly and Company

International Classification: A61K 31/47 (20060101); C07D 307/00 (20060101); C07D 405/00 (20060101)

Expiration Date: 8/08/02018