Patent Number: 7,087,714

Title: Mu-Opiod receptor splice variant polypeptides

Abstract: The present invention encompasses novel splice variant forms of the mu-opioid receptor-1 (MOR-1) and the polynucleotide sequences encoding the MOR-1 splice variants. The invention further encompasses methods of screening for compositions regulating the MOR-1 splice variant activities and the development of therapeutic modalities directed to regulating activity. Regulation of the MOR-1 splice variant activities may impact the physiologic process of analgesia.

Inventors: Pasternak; Gavril W. (New York, NY), Pan; Ying-Xian (New York, NY)

Assignee: Memorial Sloan-Kettering Cancer Center

International Classification: C07K 1/00 (20060101); C07K 14/00 (20060101); C07K 17/00 (20060101); G01N 33/53 (20060101); G01N 33/567 (20060101)

Expiration Date: 8/08/02018