Patent Number: 7,087,736

Title: Tyrosine DNA phosphodiesterases (TDP) and related polypeptides nucleic acids vectors TDP producing host cells antibodies and methods of use

Abstract: The present invention provides a nucleic acid molecule encoding a tyrosine-DNA phosphodiesterase (TDP), and a related vector, host cell, polypeptide, antibody, antisense nucleic acid molecule, and ribozyme. Also provided are a method of altering the level of TDP in a cell, tissue, organ or organism, as well as the resulting cell, tissue, organ or non-human organism, as well as a method of identifying a TDP-resistant compound, a method of assessing TDP1 activity in an animal, and a method of assessing the efficacy of a topoisomerase I inhibitor.

Inventors: Pouliot; Jeffrey (San Mateo, CA), Nash; Howard A. (Bethesda, MD)

Assignee: The United States of America as represented by the Department of Health and Human Services

International Classification: C07H 21/04 (20060101); C12N 1/21 (20060101); C12N 15/55 (20060101); C12N 15/63 (20060101); C12N 5/10 (20060101)

Expiration Date: 8/08/02018