Patent Number: 7,087,790

Title: Benzotropolone derivatives and modulation of inflammatory response

Abstract: The present invention provides novel benzotropolone derivatives represented by the general formula: ##STR00001## including neotheaflavate B and EGCGCa. The benzotropolone derivatives of the present invention are effective antioxidant and anti-inflammatory agents. The present invention also provides novel method of synthesizing benzotropolone compounds in high yields and method of treating inflammatory conditions using benzotropolone containing compounds.

Inventors: Ho; Chi-Tang (East Brunswick, NJ), Ghai; Geetha (Murray Hill, NJ), Sang; Shengmin (East Brunswick, NJ), Jhoo; Jin-Woo (Little Rock, AR), Huang; Mou-Tuan (Englewood Cliffs, NJ), Rosen; Robert T. (Monroe Township, NJ), Dushenkov; Slavik (Fort Lee, NJ)

Assignee: Rutgers, The State University of New Jersey

International Classification: C07C 45/00 (20060101); A61K 31/00 (20060101); C07C 49/115 (20060101); C07D 311/78 (20060101); C07D 315/00 (20060101)

Expiration Date: 8/08/02018