Patent Number: 7,087,808

Title: Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals

Abstract: The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embryonic implantation to obtain expression in the milk of transgenic mammal and its filial generation. The method of this invention can maintain the stable expression of multiple recombinant proteins in the transgenic mammal during lactation and stable expression amount proximate to that of the first generation in the offsprings of the transgenic non-human mammal.

Inventors: Wu; Shinn Chih (Miaoli, TW), Cheng; Teng Kuei (Taipei, TW), Chen; Chuan Mu (Taichung, TW), Lin; Shau Ping (Taipei, TW), Yen; Chon Ho (Taichung, TW), Yang; Ping Cheng (Hsinchu, TW)

Assignee: Animal Technology Institute Taiwan

International Classification: C12P 21/00 (20060101); A01K 67/00 (20060101); A01K 67/027 (20060101); C07H 21/04 (20060101); C12N 15/00 (20060101)

Expiration Date: 8/08/02018