Patent Number: 7,101,556

Title: Preparation and usage of plasmodium fusion antigen

Abstract: The invention provides a fusion protein comprising the Plasmodium merozoite surface protein-1 (MSP1) and the Plasmodium apical membrane antigen 1 (AMA-1), the encoding DNA sequence, the vector containing the sequence, the host cell containing the vector, and the genetic engineering method for preparing the fusion protein and the usage for producing anti-malarial vaccine. The AMA-1/MSP1 fusion protein of the present invention has excellent immunogenicity and can cause an effective immune response against Plasmodium in individuals.

Inventors: Pan; Weiqing (Shanghai, CN)

Assignee: Second Military Medical University

International Classification: A61K 39/00 (20060101); A61K 38/00 (20060101); A61K 39/38 (20060101); C07K 1/00 (20060101); C07H 21/04 (20060101); C12N 15/00 (20060101); C12N 15/74 (20060101)

Expiration Date: 9/05/02018