Patent Number: 7,101,562

Title: Conjugate vaccines for the prevention of dental caries

Abstract: The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and prevention of dental caries. In a preferred embodiment, a glucan polymer, preferably WSG, is covalently bound to one or more T cell-dependent antigens to form a conjugate vaccine. The T cell-dependent antigen preferably contains epitopes of one or more mutans streptococcal proteins, such as a glucosyltransferase. Moreover, one or more moieties, including haptens, may be conjugated to the glucan-T cell-dependent composition. In a preferred embodiment, these moieties are peptides which contain immunogenic epitopes corresponding to components of a mutans streptococcus.

Inventors: Lees; Andrew (Silver Spring, MD), Taubman; Martin A. (Newton, MA), Smith; Daniel J. (Natick, MA)

Assignee: The Forsyth Institute

International Classification: A61K 39/09 (20060101); A61K 39/02 (20060101); A61K 39/116 (20060101); A61K 39/385 (20060101); C07H 1/00 (20060101)

Expiration Date: 9/05/02018