Patent Number: 7,101,567

Title: Controlled release preparations having multi-layer structure

Abstract: Preparations whereby two or more drugs can be released separately at appropriate speeds depending on the disease or the release behaviors of one or more drugs can be precisely controlled, which consist of an outer layer wherein a water-soluble drug is dispersed in a carrier made of a biologically non-degradable and hydrophobic polymer material, and one or more inner layers wherein a water-soluble drug, differing in kind or concentration from the one contained in the outer layer, is dispersed in a carrier made of a biologically non-degradable and hydrophobic polymer material, and in which the outer and inner layers are concentrically located in diametral direction of rod-like preparations and both or one of the ends in the axial direction are opened so as to directly come into contact with the environment.

Inventors: Sano; Akihiko (Toyonaka, JP), Kajihara; Masako (Itami, JP), Sugie; Toshihiko (Toyonaka, JP)

Assignee: Dainippon Sumitomo Pharma Co., Ltd.

International Classification: A61F 2/00 (20060101)

Expiration Date: 9/05/02018