Patent Number: 7,101,868

Title: Substituted arylamine derivatives and methods of use

Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Inventors: Elbaum; Daniel (Newton, MA), Askew, Jr.; Benny C. (Newbury Park, CA), Booker; Shon (Thousand Oaks, CA), Germain; Julie (Medford, MA), Habgood; Gregory J. (Merrimac, MA), Handley; Michael (Greenbrae, CA), Kim; Tae-Seong (Thousand Oaks, CA), Li; Aiwen (Westlake Village, CA), Nishimura; Nobuko (West Hills, CA), Patel; Vinod F. (Acton, MA), Yuan; Chester Chenguang (Newbury Park, CA), Kim; Joseph L. (Wayland, MA), Cai; Guolin (Thousand Oaks, CA), Chen; Guoqing (Thousand Oaks, CA), Croghan; Michael (Thousand Oaks, CA), Di Pietro; Lucian V. (Wayland, MA), Dominguez; Celia (Thousand Oaks, CA), Huang; Qi (Moorpark, CA), Smith, II; Leon M. (Somerset, NJ), Tasker; Andrew (Simi Valley, CA), Xi; Ning (Thousand Oaks, CA), Xu; Shimin (Ventura, CA)

Assignee: Amgen Inc.

International Classification: A61K 31/33 (20060101); A61K 31/44 (20060101); C07D 211/62 (20060101); C07D 213/72 (20060101)

Expiration Date: 9/05/02018