Patent Number: 7,101,992

Title: Nucleic acid base pair

Abstract: A novel artificial nucleic acid base pair which is obtained by forming a selective base pair by introducing a group having steric hindrance (preferably a group having steric hindrance and static repulsion and a stacking effect) and can be recognized by a polymerase such as DNA polymerase; a novel artificial gene; and a method of designing nucleic acid bases so as to form a selective base pair with the use of steric hindrance, static repulsion and stacking effect at the base moity of the nucleic acid. An artificial nucleic acid comprising these bases; a process for producing the same; a codon containing the same; a nucleic acid molecule containing the same; a process for producing a non-natural gene by using the same; a process for producing a novel protein by using the above nucleic acid molecule or non-natural gene, and the like.

Inventors: Hirao; Ichiro (Asaka, JP), Ishikawa; Masahide (Wako, JP), Fujihara; Tsuyoshi (Wako, JP), Yokoyama; Shigeyuki (Tokyo, JP)

Assignee: Japan Science and Technology Agency

International Classification: C07H 21/00 (20060101); C07H 19/048 (20060101); C07H 19/16 (20060101)

Expiration Date: 9/05/02018