Patent Number: 7,102,009

Title: Substituted amine derivatives and methods of use

Abstract: Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Inventors: Patel; Vinod F. (Acton, MA), Askew; Benny (Newbury Park, CA), Booker; Shon (Newbury Park, CA), Chen; Guoqing (Thousand Oaks, CA), DiPietro; Lucian V. (Gloucester, MA), Germain; Julie (Somerville, MA), Habgood; Gregory J. (Merrimac, MA), Huang; Qi (Moorpark, CA), Kim; Tae-Seong (Thousand Oaks, CA), Li; Aiwen (Westlake Village, CA), Nishimura; Nobuko (West Hills, CA), Nomak; Rana (Westlake Village, CA), Riahi; Babak (Woodland Hills, CA), Yuan; Chester Chenguang (Newbury Park, CA), Elbaum; Daniel (Newton, MA)

Assignee: Amgen Inc.

International Classification: C07D 401/02 (20060101); A61K 31/44 (20060101)

Expiration Date: 9/05/02018