Patent Number: 7,102,013

Title: Methods of making amidino compounds useful as nitric oxide synthase inhibitors

Abstract: Method of making an alpha-amino acid compound having the structure of Formula 32: ##STR00001## comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: ##STR00002## where the substituents are described herein.

Inventors: Webber; Ronald Keith (St. Charles, MO), Durley; Richard C. (Chesterfield, MO), Awasthi; Alok K. (Skokie, IL), Bergmanis; Arija A. (Des Plaines, IL), Fok; Kam F. (St. Louis, MO), Ganser; Scott S. (Chicago, IL), Hagen; Timothy J. (Gurne, IL), Hallinan; E. Ann (Evanston, IL), Hansen, Jr.; Donald W. (Skokie, IL), Hickory; Brian S. (Wildwood, MO), Manning; Pamela T. (Labadie, MO), Mao; Michael (Chesterfield, MO), Moormann; Alan E. (Weldon Springs, MO), Pitzele; Barnett S. (Skokie, IL), Promo; Michelle A. (Chesterfield, MO), Schartman; Richard R. (Evanston, IL), Scholten; Jeffrey A. (Chesterfield, MO), Snyder; Jeffrey S. (Manchester, MO), Toth; Mihaly V. (St. Louis, MO), Trivedi; Mahima (Glenview, IL), Tsymbalov; Sofya (Skokie, IL), Tjoeng; Foe Siong (Ballwin, MO)

Assignee: Pharmacia Corporation

International Classification: C07D 233/40 (20060101); C07C 271/00 (20060101); C07C 323/00 (20060101)

Expiration Date: 9/05/02018