Patent Number: 7,102,018

Title: Intermediates and improved processes for the preparation of neplanocin A

Abstract: Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)dioxy]-5-hydrox- y-tricyclo[,6]dec-8-ene, which are useful for the synthesis of neplanocin A having strong antitumor activity. Improved processes for the preparation of neplanocin A, starting from optically active 2-hydroxymethyl-5-hydroxy-tricyclo[,6]deca-3,8-diene and via a key step comprising a retro-Diels-Alder reaction of the above intermediate.

Inventors: Yoshida; Naoyuki (Ichihara, JP), Ogasawara; Kunio (Sendai, JP)

Assignee: Chisso Corporation

International Classification: C07D 305/00 (20060101); C12P 41/00 (20060101)

Expiration Date: 9/05/02018