Patent Number: 7,132,098

Title: Method for the treatment of chemonucleolysis

Abstract: The invention relates to a method of treatment for a mammal in need of chemonucleolysis. The method comprising the administration of an effective proteoglycan cleaving amount of a proteoglycan-degrading enzyme and an effective amount of a growth factor effective in promoting the synthesis of a matrix component. The proteoglycan-degrading enzyme is preferably chondroitinase. The growth factor is preferably osteogenic protein. The proteoglycan-degrading enzyme and the growth factor are preferably administered simultaneously.

Inventors: Masuda; Koichi (Wilmette, IL), Thonar; Eugene J-M. A. (Lockport, IL), An; Howard (Riverwood, IL)


International Classification: A61K 38/47 (20060101)

Expiration Date: 2019-11-07 0:00:00