Patent Number: 7,132,278

Title: PAS kinase

Abstract: The invention provides methods and compositions relating to a novel kinase designated PAS Kinase (PASK). The compositions include isolated polypeptides comprising a native PASK protein or a PASK N-terminal domain and polypeptides consisting of a PASK PAS-A or PAS-B domain, as well as isolated polynucleotides encoding such polypeptides, and expression vectors and cells comprising such polynucleotides. The methods include binding assays comprising the steps of incubating a mixture comprising a subject polypeptide with a ligand under conditions wherein the polypeptide binds the ligand; and detecting binding of the polypeptide to the ligand.

Inventors: McKnight; Steven L. (Dallas, TX), Gardner; Kevin (Dallas, TX), Harper; Shannon (Dallas, TX), Rutter; Jared (Dallas, TX), Michnoff; Carolyn (Dallas, TX), Amezcua; Carlos (Dallas, TX)

Assignee: Board of Regents, The University of Texas System

International Classification: C07H 21/04 (20060101); C12N 1/16 (20060101); C12N 15/00 (20060101); C12N 5/00 (20060101)

Expiration Date: 2019-11-07 0:00:00