Patent Number: 7,132,392

Title: Inhibition of cell motility and angiogenesis by inhibitors of Grb2-SH2-domain

Abstract: Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. The present invention further provides methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures ##STR00001## ##STR00002##

Inventors: Bottaro; Donald P. (Kensington, MD), Atabey; Safiye N. (Izmir, TR), Soriano; Jesus V. (Washington, DC), Breckenridge; Diane E. (Kensington, MD), Yao; Zhu-Jun (Shanghai, CN), Gao; Yang (Branford, CT), Burke, Jr.; Terrence R. (Bethesda, MD)

Assignee: The United States of America as represented by the Department of Health and Human Services

International Classification: A61K 38/08 (20060101); A61K 38/06 (20060101); A61K 38/07 (20060101); C07K 5/08 (20060101); C07K 5/10 (20060101); C07K 7/04 (20060101)

Expiration Date: 2019-11-07 0:00:00