Patent Number: 7,132,401

Title: Beta-secretase substrates and uses thereof

Abstract: The present invention provides synthetic .beta.-secretase peptide substrates useful in various assays for measuring .beta.-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.

Inventors: Brady; Stephen F. (Philadelphia, PA), Bruce; James E. (Schwenksville, PA), Chen-Dodson; Elizabeth (Souderton, PA), Garsky; Victor (Blue Bell, PA), Li; Yueming (New York, NY), Sardana; Mohinder (Lansdale, PA), Shafer; Jules A. (Gwynedd Valley, PA), Tang; Xiaoting (Lansdale, PA)

Assignee: Merck & Co., Inc.

International Classification: A61K 38/08 (20060101)

Expiration Date: 2019-11-07 0:00:00