Patent Number: 7,132,442

Title: 6H-thieno[2, 3-b]pyrrole derivatives as antagonists of gonadotropin releasing hormone (GnRH)

Abstract: The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.

Inventors: Foote; Kevin Michael (Cheshire, GB), Matusiak; Zbigniew (Cheshire, GB), Dossetter; Alexander Graham (Cheshire, GB), Arnould; Jean Claude (Reims Cedex 2, FR), Lamorlette; Maryannick Andree (Reims Cedex 2, FR), Delouvrie; Benedicte (Reims Cedex 2, FR), Hamon; Annie (Reims Cedex 2, FR)

Assignee: AstraZeneca AB

International Classification: A61K 31/40 (20060101); A61K 31/381 (20060101); A61K 31/407 (20060101); C07D 207/06 (20060101); C07D 401/00 (20060101); C07D 495/02 (20060101)

Expiration Date: 2019-11-07 0:00:00