Patent Number: 7,132,513

Title: Bifunctional chelating agent

Abstract: The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents --NO.sub.2, --NH.sub.2, --NCS, --NHCOCH.sub.2-Z. NHCO--W--COCNHS, --NH-Q, --NHCS-Q, --NHCOCH.sub.2-Q, or --NHCO(CH.sub.2)m ?-Q where Q is an hapten chosen from the group consisting of steroids, enzymes, proteins, monoclonal antibodies, chimeric antibodies, or fragments thereof or any activated linker ready for coupling reaction, Y is CO.sub.2H or PO.sub.3H.sub.2 W is --(CH.sub.2).sub.m-- m is an integer from 1 to 10. Z is chloride, bromide or iodine ##STR00001## ##STR00002##

Inventors: Ouadi; Ali (Eggensteim, DE), Gestin; Jean-Francois (Mauve sur Loire, FR), Apostolidis; Christos (Heidelberg, DE)

Assignee: European Community

International Classification: C07K 16/00 (20060101); A61K 51/00 (20060101); C07D 259/00 (20060101); C12N 9/96 (20060101); G01N 33/534 (20060101)

Expiration Date: 2019-11-07 0:00:00