Patent Number: 7,132,533

Title: Tricyclic compounds protein kinase inhibitors for enhancing the efficacy of anti-neoplastic agents and radiation therapy

Abstract: Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the following formula (wherein R.sup.2, R.sup.3 and R.sup.4 are as defined in the specification) ##STR00001## pharmaceutical compositions containing effective amounts of said compounds or their salts are useful as a single agent or in combination with an anti-neoplastic agent or therapeutic radiation having an anti-neoplastic effect for treating diseases or conditions such as cancers.

Inventors: Benedict; Suzanne (Carlsbad, CA), Bennett; Michael (San Diego, CA), Ninkovic; Sacha (Carlsbad, CA), Teng; Min (San Diego, CA), Rui; Eugene (San Diego, CA), Wang; Fen (San Diego, CA), Wang; Yong (San Diego, CA), Zhu; Jinjiang (San Diego, CA)

Assignee: Agouron Pharmaceuticals, Inc.

International Classification: C07D 487/02 (20060101); A61K 31/551 (20060101)

Expiration Date: 2019-11-07 0:00:00