Patent Number: 7,202,226

Title: Augmentation of wound healing by elF-4E mRNA and EGF mRNA

Abstract: There is provided a method of augmenting transient protein synthesis in a cell by delivering to the cell mRNA functionally related to protein production. Also provided is a method of augmenting transient protein synthesis in cells by increasing protein synthesis of growth factors from endogenous cellular mRNA and exogenous mRNA delivered to the cells. A treatment for transiently increasing protein production in cells, said treatment comprising mRNA functionally related to protein production is also provided. There is provided a method of augmenting wound healing by delivering mRNA functionally related to wound healing. Further provided is a therapeutic for transiently increasing protein synthesis in cells, said therapeutic comprising mRNA related to protein production.

Inventors: Murray; Mary Theresa (Grosse Pointe, MI), Dulchavsky; Scott Alexander (Grosse Pointe Park, MI)

Assignee: Detroit R & D

International Classification: A61K 48/00 (20060101)

Expiration Date: 2019-04-10 0:00:00