Patent Number: 7,202,349

Title: Intrinsically fluorescent, self-multimerizing MHC fusion proteins and complexes thereof

Abstract: Presented are intrinsically fluorescent, self-multimerizing MHC fusion proteins, and complexes assembled therefrom that are capable of detectably labeling antigen-specific T lymphocytes. Also presented are methods for labeling antigen-specific T lymphocytes with the intrinsically fluorescent complexes of the present invention, and methods, particularly flow cytometric methods, for detecting, enumerating, enriching, and depleting antigen specific T lymphocytes so labeled.

Inventors: Davis; Kenneth A. (Mountain View, CA), Wei; Bing-Yuan (San Diego, CA)

Assignee: Becton, Dickinson and Company

International Classification: C07K 14/74 (20060101); C12N 5/10 (20060101); G01N 33/53 (20060101); G01N 33/532 (20060101)

Expiration Date: 2019-04-10 0:00:00