Patent Number: 7,465,553

Title: Psoriasin expression by breast epithelial cells

Abstract: The invention features methods of diagnosing high grade ductal carcinoma in situ (DCIS) These methods involve measuring: (1) the level of HID-5 in a body fluid (e.g., blood or urine) of a subject suspected of having, or at risk of having, high grade DCIS; or (2) the level of HID-5 gene expression in breast tissue from a subject suspected of having, or at risk of having, high grade DCIS. The invention also embodies a method of inhibiting expression of HID-5 protein in DCIS cells and methods of treating a subject suspected of having, or at risk of having, high grade DCIS.

Inventors: Polyak; Kornelia (Brookline, MA), Enerback; Charlotta (Gothenburg, SE)

Assignee: Dana-Farber Cancer Institute, Inc.

International Classification: G01N 33/536 (20060101)

Expiration Date: 2021-12-16 0:00:00