Patent Number: 7,465,572

Title: De-immunized streptokinase

Abstract: A target protein is rendered less immunogenic to a given species by (a) determining at least part of the amino acid sequence of the target protein; (b) identifying in the amino acid sequence one or more potential epitopes for T-cells ("T-cell epitopes") of the given species; and (c) modifying the amino acid sequence to eliminate at least one of the T-cell epitopes identified in step (b) to reduce the immunogenicity of the protein when exposed to the immune system of the given species.

Inventors: Carr; Francis Joseph (Aberdeen, GB), Adair; Fiona Suzanne (Aberdeen, GB), Hamilton; Anita Anne (Aberdeen, GB), Carter; Graham (Aberdeen, GB)

Assignee: Merck Patent GmbH

International Classification: C12N 9/70 (20060101); A61K 39/395 (20060101); A61K 38/43 (20060101); C07K 14/00 (20060101); C12P 21/06 (20060101); C12N 9/00 (20060101)

Expiration Date: 2021-12-16 0:00:00