Patent Number: 7,465,738

Title: Compounds useful as promoters of SMN2

Abstract: The present invention relates to compounds useful as promoters of the SMN2 gene. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of Spinal Muscular Atrophy.

Inventors: Jarecki; Jill (San Diego, CA), Chen; Xiaocun (San Diego, CA), Hurley; Dennis James (San Marcos, CA), Makings; Lewis R. (Encinitas, CA), Miller; Mark T. (San Diego, CA), Pollok; Brian (Middleton, WI), Stack; Jeffrey H. (San Diego, CA), Whitney; Michael A. (San Diego, CA)

Assignee: Vertex Pharmaceuticals Incorporated

International Classification: A61K 31/517 (20060101); A61K 31/55 (20060101); C07D 239/72 (20060101)

Expiration Date: 2021-12-16 0:00:00