Patent Number: 7,534,802

Title: Compounds having 4-pyridylalkylthio group as substituent

Abstract: A subject of the present invention is to provide a novel aromatic five- or six-memberd heterocyclic derivative having 4-pyridylalkylthio as a substituent or a salt thereof which is useful as a pharmaceutical. Compound represented by the following general formula [I] or salts thereof are useful as therapeutic agents for diseases in which angiogenesis or augmentation of vascular permeability is involved. In the formula, ring "A" is a benzene ring or an aromatic five- or six-memberd heterocycle which can be fused with a cycloalkane ring, "B" is alkylene, R.sup.1 and R.sup.2, the same or different, are H, OH, substituted or unsubstituted alkoxy and the like, X and Y, the same or different, are group(s) selected from H, halogen, OH, substituted or unsubstituted alkoxy and the like respectively, p is 0, 1 or 2, and q is 0 or 1.

Inventors: Honda; Takahiro (Ikoma, JP), Tajima; Hisashi (Ikoma, JP), Sasabuchi; Yoshimasa (Ikoma, JP), Kawashima; Kenji (Ikoma, JP), Okamoto; Kazuyoshi (Ikoma, JP), Yamamoto; Minoru (Ikoma, JP), Ban; Masakazu (Ikoma, JP)

Assignee: Santen Pharmaceutical Co., Ltd.

International Classification: C07D 401/14 (20060101); A61K 31/444 (20060101)

Expiration Date: 2021-05-19 0:00:00