Patent Number: 7,534,857

Title: Methods and compositions for the treatment and prevention of staphylococcal infections

Abstract: A biologically pure RNAIII inhibiting peptide (RIP), that includes five contiguous amino acids of the sequence YX.sub.2PX.sub.1TNF, where X.sub.1 is C, W, I or a modified amino acid, and X.sub.2 is K or S is provided. The RIP further includes amino acids having a sequence that differs from the sequence YX.sub.2PX.sub.1TNF by two substitutions or deletions, where X.sub.1 is C, W, I or a modified amino acid, and X.sub.2 is K or S. This agent offers improved protection against and treatment of staphylococcal infections, and related bacteria infections, in mammals.

Inventors: Balaban; Naomi (Hopkinton, MA)

Assignee: Centegen, Inc.

International Classification: C07K 2/00 (20060101); A61K 38/00 (20060101); C07K 7/00 (20060101); C07K 5/00 (20060101); C07K 4/00 (20060101); A61K 38/04 (20060101); A61K 39/00 (20060101); A61K 39/02 (20060101); A61K 39/085 (20060101); A61K 39/09 (20060101); A61K 39/38 (20060101); C07K 14/00 (20060101); C07K 16/00 (20060101); C07K 17/00 (20060101)

Expiration Date: 2021-05-19 0:00:00