Patent Number: 7,611,718

Title: Attenuation of cytomegalovirus virulence

Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.

Inventors: Kemble; George (Saratoga, CA), Duke; Gregory M. (Redwood City, CA), Spaete; Richard (Emerald Hills, CA)

Assignee: MedImmune, LLC

International Classification: A61K 39/12 (20060101); A61K 39/245 (20060101); C12Q 1/70 (20060101)

Expiration Date: 1/03/02017