Patent Number: 7,611,844

Title: Methods for detecting asymmetric dimethylarginine in a biological sample

Abstract: The present invention provides methods of detecting asymmetric dimethylarginine (ADMA) in a sample, particularly a sample that may contain symmetrical dimethylarginine (SDMA) and/or arginine. The methods generally involve modifying any SDMA and arginine in the sample such that SDMA and arginine are readily distinguishable from ADMA; and detecting ADMA. The invention further provides antibodies specific for ADMA; antibodies specific for modified SDMA; and antibodies specific for modified arginine. The invention further provides kits for practicing the subject methods.

Inventors: Lin; Ken Y. (Boston, MA), Cooke; John (Palo Alto, CA)

Assignee: Board of Trustees of the Leland Stanford Jr. University

International Classification: G01N 33/53 (20060101); G01N 33/543 (20060101)

Expiration Date: 1/03/02017