Patent Number: 7,611,856

Title: Mass spectrometry-based methods for detection and differentiation of botulinum neurotoxins

Abstract: The present invention is directed to a method for detecting the presence of clostridial neurotoxins in a sample by mixing a sample with a peptide that can serve as a substrate for proteolytic activity of a clostridial neurotoxin; and measuring for proteolytic activity of a clostridial neurotoxin by a mass spectroscopy technique. In one embodiment, the peptide can have an affinity tag attached at two or more sites.

Inventors: Schmidt; Jurgen G. (Los Alamos, NM), Boyer; Anne E. (Atlanta, GA), Kalb; Suzanne R. (Atlanta, GA), Moura; Hercules (Tucker, GA), Barr; John R. (Suwannee, GA), Woolfitt; Adrian R. (Atlanta, GA)

Assignee: Los Alamos National Security, LLC

International Classification: G01N 30/72 (20060101)

Expiration Date: 1/03/02017