Patent Number: 7,611,870

Title: Methods for identifying cancer risk

Abstract: The present invention provides methods and kits for identifying an increased risk of developing cancer in a subject. The methods include analyzing a first biological sample, such as a blood sample, from the subject for loss of imprinting of the IGF2 gene. According to the methods a loss of imprinting is indicative of an increased risk of developing cancer. The method can include analyzing genomic DNA from the sample for altered methylation of the IGF2 gene. The altered methylation for example includes hypomethylation of a differentially methylated region of IGF2, corresponding to SEQ ID NO:1 or a polymorphism thereof. The method can be performed on a subject having no apparent or suspected hyperproliferative disorder such as cancer.

Inventors: Feinberg; Andrew P. (Lutherville, MD)

Assignee: The Johns Hopkins University School of Medicine

International Classification: C12P 19/34 (20060101); C12Q 1/68 (20060101); C07H 21/02 (20060101); C07H 21/04 (20060101)

Expiration Date: 1/03/02017