Patent Number: 7,611,888

Title: Rotaxane compound, rotaxane-bonded solid substrate, and biochip using the same

Abstract: The present disclosure provides a rotaxane compound that can be used to separate molecules within a linkage layer formed on a solid substrate of a biochip by a predetermined distance. The compound is represented by Formula 1, in which a compound of Formula 3 vertically passes through a cavity of cucurbituril or its derivative of Formula 2. It further provides gene chips, protein chips and sensors for biomaterial assays which use the rotaxane molecules to allow biomaterials to be immobilized on a linkage layer such that they are regularly spaced apart from each other by a predetermined distance.

Inventors: Kim; Kimoon (Pohang, KR), Kang; Jin Koo (Pohang, KR), Jeon; Woo Seong (Pohang, KR), Noh; Miran (Pohang, KR), Kim; Dongwoo (Pohang, KR), Baek; Kangkyun (Pohang, KR)

Assignee: Postech Foundation

International Classification: C12M 1/34 (20060101); C07D 245/00 (20060101); G01N 33/552 (20060101); G01N 33/53 (20060101); C12Q 1/68 (20060101); C07K 1/10 (20060101)

Expiration Date: 1/03/02017