Patent Number: 7,612,047

Title: Degradation-resistant mononucleoside phosphate compounds

Abstract: The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that has been modified by attaching a degradation-resistant substituent on the terminal phosphate of a polyphosphate mononucleotide. By attaching this degradation-resistant substituent, the stability from degradation matches or exceeds those of certain dinucleotides. The mononucleoside phosphate compounds of the present invention are useful in preventing and treating epithelial tissue diseases or diseases or disorders associated with platelet aggregation.

Inventors: Douglass, III; James G. (Apex, NC), Yerxa; Benjamin R. (Raleigh, NC), Shaver; Sammy R. (Chapel Hill, NC), Peterson; Ward M. (Morrisville, NC), Brown; Edward G. (Cary, NC), Crean; Christopher S. (Pittsboro, NC), Boyer; Jose L. (Chapel Hill, NC)

Assignee: Inspire Pharmaceuticals, Inc.

International Classification: A01N 43/04 (20060101); A61K 31/70 (20060101)

Expiration Date: 1/03/02017