Patent Number: 7,612,052

Title: Combinations comprising epothilones and pharmaceutical uses thereof

Abstract: The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I ##STR00001## wherein A represents O or NR.sub.N, wherein R.sub.N is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond, in which the active ingredients (a) and (b) are present in each case in free form or in the form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition, a commercial package or product comprising such a combination; the use of such a combination for the preparation of a medicament for the delay of progression or treatment of a proliferative disease and to a method of treatment of a warm-blooded animal.

Inventors: Rothermel; John David (Sunset Beach, NC), Wartmann; Markus (Riehen, CH), Wood; Jeanette Marjorie (Biel-Benken, CH)

Assignee: Novartis AG

International Classification: A61K 31/66 (20060101); A61K 31/28 (20060101); A61K 31/425 (20060101)

Expiration Date: 1/03/02017