Patent Number: 7,612,079

Title: 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders

Abstract: The present invention relates to compounds of formula I ##STR00001## or a pharmaceutically acceptable salt thereof wherein R.sub.2 is 2-hydroxymethylpyrrolidin-1-yl, or NHCH(R.sub.4)CH(R.sub.3)OH, wherein R.sub.3 is hydrogen or methyl and R.sub.4 is methyl, ethyl or isopropyl; R.sub.6 is 3-nitrophenylamino, 3,4-dimethoxybenzylamino, 3-iodobenzyl-amino, pyrid-2-yl-methylamino, pyrid-4-yl-methylamino or indan-5-amino; R.sub.9 is isopropyl or cyclopentanyl. In a further aspect, the invention relates to pharmaceutical compositions comprising said compounds, and the use thereof in treating antiproliferative disorders and or viral disorders.

Inventors: Fischer; Peter Martin (Angus, GB), Jarman; Mike (London, GB), McDonald; Ted (Reigate, GB), Nutley; Bernard (Sutton, GB), Raynaud; Florence (London, GB), Wilson; Stuart (Sutton, GB), Workman; Paul (Abinger Common, GB)

Assignee: Cyclacel Limited

International Classification: C07D 473/16 (20060101); A61K 31/52 (20060101); A61P 35/00 (20060101); A61P 17/06 (20060101); A61P 35/02 (20060101); C07C 215/08 (20060101)

Expiration Date: 1/03/02017